3-Methylcholanthrene uptake and metabolism in organ culture

The effect of 3-methylcholanthrene on rat trachea in organ culture.

Axonal sprouts and ( 3 H)norepinephrine uptake by superior cervical ganglia in organ culture.

Superior cervical ganglia from adult rats maintained in organ culture show a progressive increase in the rate of uptake of [(3)H]norepinephrine. The enhanced uptake of norepinephrine is a consequence of the development of axonal sprouts. Formation of axonal sprouts, which appear to have many of the properties of sympathetic nerve endings, is inhibited by colchicine and vinblastine, presumably b...

: examining l2 teachers’ corrective feedback types in relation to learners’ uptake, proficiency levels, and context types

abstract this study investigates the teachers’ correction of students’ spoken errors of linguistic forms in efl classes, aiming at (a) examining the relationship between the learners’ proficiency level and the provision of corrective feedback types, (b) exploring the extent to which teachers’ use of different corrective feedback types is related to the immediate types of context in which err...

Metabolism, mitochondrial uptake and toxicity of 2', 3'-dideoxycytidine.

2',3'-Dideoxycytidine (ddCyd) is a prescription anti-retroviral drug that causes mitochondrial toxicity and peripheral neuropathy. ddCyd is actively phosphorylated by cytosolic deoxycytidine kinase and nucleoside (di)phosphate kinase to the 5'-triphosphate derivative. However, 2',3'-dideoxycytidine 5'-diphosphocholine (ddCDP-choline) was also found in human cells incubated with ddCyd. In this p...

The tumor-inhibitory effects of 3-methylcholanthrene on transplantable and 3-methylcholanthrene-induced tumors in C3H mice.

When 3-methylcholanthrene therapy was initiated 8 days after transplantation of the myeloma X5568 in CgH mice, retardation and even complete suppression of the transplant resulted. It did not appear that a general depression of somatic growth eouM account for this effect. Histological examination of the carcinogen-treated myeloma revealed peripheral necrosis, reduction in mitotic figures, witho...